How Does Modified GRF (1-29) Work?

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How Does Modified GRF (1-29) Work?

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Modified GRF (1-29), called mod GRF for short, is an analogue of human growth-hormone releasing hormone (GHRH). GHRH, which is produced by the hypothalamus, causes the release of growth hormone from the anterior pituitary. Growth hormone (GH), in turn, affects various end-organ receptors to stimulate muscle growth, bone growth, calcium retention, and a host of other things.

 

The GHRH-GH Axis and Modified GRF (1-29)

 

The GHRH-GH axis is the technical term applied to the system of hormones and organs that regulate and respond to growth hormone. The entire process starts in the hypothalamus, a small region of the brain that sits just above the brain stem. The hypothalamus produces a number of hormones, one of which is referred to as growth-hormone releasing hormone (GHRH). GHRH acts on the pituitary gland, which sits just below the hypothalamus, causing it to release growth hormone. Growth hormone then goes on to affect liver, bone, fat, muscle, and thyroid tissues.

 

GHRH and GH hormone levels are regulated by feedback from the various organs that GH affects. For instance, a rise in levels of Insulin-like growth factor 1 (IGF-1) will suppress GH and GHRH production in the pituitary and hypothalamus, respectively.

 

The regulation of GHRH and GH is complex and subject to a number of positive and negative feedback mechanisms. These mechanisms serve to regulate GH levels and to ensure proper development of body tissues. Exogenous (outside of the body) analogues of GHRH have all of the same effects of GHRH, but are not subject to the feedback mechanisms that normally regulate GHRH.

 

Mod GRF is similar to GHRH, but is only 29 amino acids long rather than 44 amino acids long. Mod GRF has the same effects as GHRH, even though it is smaller. The molecule itself has been heavily manipulated to increase its half-life, prevent degradation, and increase potency. Mod GRF (1-29) comes in DAC and no-DAC forms. DAC, or Drug Affinity Complex, is a protein that is added to the end of a molecule to prevent it from degrading in the bloodstream of test animals. Modified GRF (1-29) with DAC is known as CJC-1295 – DAC while standard modified GRF (1-29) is known as CJC 1295 – no DAC. So, how do you buy modified GRF (1-29).

 

Receptor Binding

 

The primary function of GHRH and any analogue of it is to bind to GHRH receptors (GHRHRs) on the anterior pituitary gland. Binding, in turn, causes the release of GH. Analogues of GHRH can be manipulated by scientists to alter their effects and their durations of action. Mod GRF (1-29) is just one of several analogues that have been created and modified in order to produce varying effects on GH release.

 

Effects of Growth Hormone

ghrh

GH has a number of biological actions. In fact, GH has so many functions in mammalian physiology that they haven’t all been uncovered yet. A few known effects include

 

The above effects of growth hormone lead to decreased LDL (bad) cholesterol, increased muscle and bone mass, increased aerobic capacity, increased fat burning, and even improvements in cognitive function. These effects have all been seen in both animal and human subjects who had GH replacement after being diagnosed with growth hormone deficiency.